Diabetic Perspectives
نویسنده
چکیده
This article gives an overview of two recent trials investigating rosiglitazone, a thiazolidinedione, in its potential to prevent type 2 diabetes (T2D) and in its effectiveness in monotherapy. Thiazolidinediones are among the most important developments of recent years for combating T2D and therefore worth to revisit. The possible influence of thiazolidines in improving beta-cell function is discussed as well as the potential effects on insulin resistance and obesity. Novel, incretin-based therapies (GLP-1 analogues and DPP-4 inhibitors) and their effects on beta-cell function and beta-cell mass are also summarized and critically evaluated.
منابع مشابه
Diabetic Retinopathy: Animal Models, Therapies, and Perspectives
Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great efforts have been made to uncover the mechanisms underlying the pathology of DR, the exact causes of DR remain largely unknown. Because of multifactor involvement in DR etiology, currently no effective therapeutic treatments for DR are available. In this paper, we review the pathology of DR, commonly used an...
متن کاملLow back pain in diabetes mellitus and importance of preventive approach.
BACKGROUND Musculoskeletal pain is known to be a common problem in diabetic patients. In spite of this fact, there is little information about epidemiology aspect of Low Back Pain (LBP) and necessity of taking preventive approach in diabetic patients. The aim of this study was to determine the prevalence of LBP in diabetic patients and its comparison with non-diabetic subjects. METHODS Low ba...
متن کاملDiabetes in India: Perspectives on Awareness and Care
Background and aims: Diabetes is a major killing recognized as a silent epidemic globally problem. India has the highest number of diabetes cases in the world causing huge morbidity and economic losses to the country. There were 66.8 million adults suffering from with diabetes in India in 2014, which is expected to rise by 63% to 109 million by 2035. Diabetes led to at least US...
متن کاملPathogenic perspectives for the role of inflammation in diabetic nephropathy.
Diabetes and its complications have become a public health problem. One of the most important complications is diabetic nephropathy, which is nowadays the main cause of chronic renal failure. In spite of our greater understanding of this complication, the intimate mechanisms leading to the development and progression of renal injury are not well understood. New perspectives in activated innate ...
متن کاملGene Therapies for Neovascular Age-Related Macular Degeneration.
Pathological neovascularization is a key component of the neovascular form (also known as the wet form) of age-related macular degeneration (AMD) and proliferative diabetic retinopathy. Several preclinical studies have shown that antiangiogenesis strategies are effective for treating neovascular AMD in animal models. Vascular endothelial growth factor (VEGF) is one of the main inducers of ocula...
متن کامل